IV Preparation

DOXIL® is a translucent, red liposomal dispersion that must be reconstituted before use. Use the tabs below to learn how to properly prepare, store, handle, and dispose of DOXIL®.

  • Preparation
  • Storage
  • Proper handling
    and disposal
  • Prior to administration, the appropriate dose of DOXIL® must be diluted in 5% Dextrose Injection, USP (D5W)

  • Do not use any diluent other than the D5W Injection
    • Do not mix with saline
    • Do not use any bacteriostatic agent, such as benzyl alcohol
  • Do not mix with other drugs
  • Refrigerate unopened vials of DOXIL® at 2°C to 8°C (36°F to 46°F); avoid freezing
    • Prolonged freezing (>1 month) may adversely affect liposomal drug products
  • Diluted DOXIL® should be refrigerated at 2°C to 8°C (36°F to 46°F) and administered within 24 hours
  • As with any cytotoxic agent, caution should be exercised in the handling, preparation, and disposal of DOXIL®
  • The use of gloves is required
  • If DOXIL® comes into contact with skin or mucosa, immediately wash the affected area thoroughly with soap and water
  • Aseptic technique must be strictly observed since no preservative or bacteriostatic agent is present in DOXIL®
  • Visually inspect reconstituted drug for particulate matter and discoloration prior to administration; do not use if precipitate or foreign matter is present