Treatment Considerations
When choosing a chemotherapeutic agent, primary treatment considerations include dosing schedule, efficacy, and tolerability. An appropriate balance of all 3, tailored to each patient’s specific needs, may help achieve overall clinical benefit.
S.E.T. (Schedule, Efficacy, Tolerability) is an acronym for these treatment considerations. S.E.T. provides a framework to discuss the interaction and balance of all 3 of these factors, helping you identify which therapy best meets your patient’s needs.
The balance of S.E.T. is dependent on disease characteristics, goals of therapy, and patient factors.
In the treatment of ovarian cancer, goals of therapy vary depending on the extent of disease. Specifically, in recurrent ovarian cancer, the point at which relapse occurs can influence treatment decisions.
Considerations for Treatment of Ovarian Cancer1-7
- Cure or durable response and progression-free survival are the primary goals of first-line treatment4,5
- In the recurrent setting, it is best to choose an efficacious agent, while also considering1,3,8:
- Tolerability profile
- A convenient schedule that meets patients’ needs
- Platinum-refractory and platinum-sensitive may be considered 2 different disease states1,6
- Thus, the approach to managing each may be different
