Dosing Guidelines
A Minimum of 4 Courses Is Recommended
- Adminster DOXIL® IV at a dose of 50 mg/m² once a month
- An initial rate of 1 mg/min should be used with the first dose of DOXIL®. If no infusion-related adverse reactions are observed, increase the rate to complete administration over 1 hour
- Pretreatment with or concomitant use of antiemetics should be considered
- Dose every 4 weeks for as long as the patient does not clinically progress, continues to tolerate treatment, and shows no evidence of cardiotoxicity
- Dose may be delayed or reduced to manage adverse reactions such as hand-foot syndrome, stomatitis, or hematologic toxicities. Once the dose has been reduced, it should not be increased at a later time
- Median time to response in clinical trials was 4 months
Use this body surface area calculator to assist in calculating dosages for DOXIL® treatments.
Managing Hepatically Impaired Patients
- Prior to DOXIL® administration, evaluation of hepatic function is recommended
- DOXIL® dosage should be reduced in patients with impaired hepatic function if the bilirubin is elevated as follows
- Give 1/2 normal dose if serum bilirubin is 1.2 to 3.0 mg/dL
- Give 1/4 normal dose if serum bilirubin is >3.0 mg/dL
For your patients who experience adverse reactions, including hematologic toxicity, hand-foot syndrome, and stomatitis, dosing modifications may help. Find out more.
